Alzheimer’s may be driven far more by genetics than previously thought, with one gene playing an outsized role. Researchers ...

A protective APOE gene variant is enriched in Super Agers—people over 80 who think like 50‑year‑olds—cutting Alzheimer’s risk ...

Using the largest sample of super-agers to date, scientists have found convincing evidence that supports what many of us have ...

Getting on in years has arguably always been a puzzle. There's the 82-year-old part-time farmer down the road who remains ...

Two rare mutations in the APOE gene ― APOE ε4 (R251G) and APOE ε3 (V236E) ― dramatically reduce the risk of developing Alzheimer's disease (AD), results of a large genetic association study show. APOE ...

Some seniors may carry a protective gene that keeps their minds decades younger.

Our episodic memory – the ability to recall past events and experiences – is known to decline as we age. Exactly how and why ...

A flurry of recent studies implicating microglia as key players in neurodegenerative diseases, particularly Alzheimer’s, has cued many labs to try to figure out how these cells function in health, and ...

The gene variant posing the greatest genetic risk of late-onset Alzheimer's disease (AD) is called APOE-ε4. A different variant of the same gene, APOE-ε2, is thought to confer protection against AD.

People often worry they will get Alzheimer’s disease if their parents did. But engaging in a healthy lifestyle can outweigh ...

ApoE just got a little more interesting—if that’s possible. While scientists may debate how this apolipoprotein contributes to Alzheimer’s disease pathology, nobody disputes that one of its isoforms, ...