Both CBEs and ABEs have been extensively engineered to improve their efficiency, specificity, and targeting range, enabling a wide variety of base pair conversions across the genome. Base editing can ...

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St.

About 15 years ago, David Liu, PhD, a young chemistry professor at Harvard University, launched an unusually profitable extracurricular activity. Every few months, he’d accompany a handful of students ...

Point mutations change one or very few nucleotides in DNA, but they cause an estimated 30,000 genetic diseases in humans. For example, children born with Progeria age rapidly and die before adulthood, ...

CRISPR-Cas9 gene editing relies on a guide RNA that binds to a desired DNA sequence and a Cas9 enzyme that cuts both strands of DNA at that site, creating a double-strand break. Scientists edit the ...

A collaboration between researchers at the Organoid group at the Hubrecht Institute and the Princess Máxima Center (both Utrecht, The Netherlands), has successfully utilized base editors to integrate ...

While researchers have long appreciated the enormous potential of genome editing to treat disease, applications of these technologies in humans have historically been limited by safety concerns. Even ...

A 13-year-old girl was the world's first patient to get a cell therapy called base editing in May. The experimental treatment has put her leukemia in remission for six months and counting. Base ...