Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food. However, bile acids can become a ...

A new study reveals how a critical imbalance in bile acids—the substances made by the liver that help digest fats—can trigger liver diseases, including hepatocellular carcinoma (HCC), the most common ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Salk Institute scientists discovered that bile acids in the liver can weaken immune cell function, making immunotherapy less effective against liver cancer. They pinpointed specific bile acids that ...

Rectify Pharma is using its ABCs to treat PSC. Three years after raising $100 million in series A funds, the Atlas Venture-backed biotech has chosen a lead drug candidate: the small molecule RTY-694, ...

The image depicts gut microbes producing secondary bile acids to support the host’s immune defense against cancer. Microbiota-derived bile acids (shown in light green) blocked the androgen receptor ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...