ALS is the most common form of motor neuron disease in the adult. Both sporadic and familial forms exist, and with the discovery of a GGGGCC (G4C2) intronic repeat expansion in the C9ORF72 gene, a ...

The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Researchers from VIB and UAntwerp, headed ...

A new study has shed light on how the most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) — a GGGGCC-repeat expansion in C9orf72 — exerts its toxic effect ...

As the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), repeat expansions in the C9ORF72 gene spew a poisonous brew of abnormal RNAs and small ...

“It’s a stellar example of how basic science approaches can have direct application to human diseases,” said Benjamin Wolozin, Boston University, who was not involved in the work. Eukaryotic cells ...

Breakthroughs, discoveries, and DIY tips sent six days a week. Terms of Service and Privacy Policy. We’ve known for a while that having a mutation in one specific ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction.

BioWorld - Thursday, May 22, 2025 Breaking News: 100 days of uncertainty See today's BioWorld Science Home » CRISPR/Cas9-based removal of a repeat expansion in C9ORF72 counteracts disease mechanisms ...

The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Researchers have demonstrated that if an ...