A new way to map how cells choose their fate

Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct ...

Scientists develop targeted therapy for T-cell lymphomas and leukemias

Researchers at the Johns Hopkins Kimmel Cancer Center's Ludwig Center developed a new treatment that selectively targets ...
The New England Journal of Medicine

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimislecel ...
The New England Journal of Medicine

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats ...
The New York Times

First Day of a ‘New Life’ for a Boy With Sickle Cell

Kendric Cromer, 12, is among the first patients to be treated with gene therapy just approved by the F.D.A. that many other patients face obstacles to receiving. By Gina Kolata Photographs by Kenny ...
The New York Times

Life Without Sickle Cell Beckons Boy Who Completed Gene Therapy

After 44 days, Kendric Cromer, 12, left the hospital. While his family feels fortunate that he was the first to receive a treatment, their difficult experiences hint at what others will be up against.