Abnormal cell proliferation is a major hallmark of cancer. Several proteins are involved in the cell cycle, and most of these regulate the positive or negative control of cyclin-dependent kinases.

Protein post-translational modifications are crucial in driving cancer development and progression. The SUMO E3 ligase PIAS4 regulates various cellular processes, thereby promoting tumour advancement.

The regulation of cellular functions such as preserving genetic information, producing energy and building blocks, and sending and receiving signals to and from the microenvironment is achieved ...

Chemopproteomic methods (ABPP) identify a stereoprobe that interacts with a cysteine in the cell cycle protein MAD2L1BP and disrupts its interaction with other proteins. Disruption of this protein ...

A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating ...

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine ...