Fluorine can be highly advantageous in pharmaceutical and agrochemical compounds. One or just a few atoms in an organic molecule can dramatically alter its chemical and biological nature, including ...

The recognition of chirality in bioactive molecules is as old as modern organic chemistry itself. Pioneering work by Jean-Baptiste Biot, Louis Pasteur, Emil Fischer, and J. vant Hoff established ...

A newly designed thiol catalyst for radical cyclization reactions is the result of a long and storied battle to control the reactivity of carbon-centred radicals. Since Gomberg first discovered a ...

Asymmetric processes have become increasingly popular in the synthesis of pharmaceutical compounds in recent years, for reasons including the growing prevalence of more complicated molecular ...

NATURE HAS A WAY OF KNOWING how to make things work. Reactions often run in a catalytic mode, and material use, energy, and waste are minimized. Many molecules are chiral, and their unique handedness ...