The major histocompatibility complex class I (MHC-I) antigen presentation pathway is central to the adaptive immune response. In this process, intracellular proteins are degraded primarily by the ...
Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the ...
To activate T cells, DCs take up, process, and present antigens as part of major histocompatibility complexes (MHCs) that interact with T cell receptors. Therefore, Curtis and her team set out to ...
Immunotherapy has transformed cancer treatment, but persistent challenges, such as T cell exhaustion, limited persistence, and variability in response, continue to impact therapeutic success.
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