Addressing a fundamental limitation in CRISPR-Cas genome editing, researchers have developed new engineered Cas9 variants that nearly eliminate the need for a protospacer adjacent motif known as PAM.

Unless you are a bacterium, you may want to go PAMless. PAMs, or protospacer adjacent motifs, are what bacteria use to distinguish their own DNA from invasive viral DNA. That is, PAMs help spare ...

Alongside Dennis vanEngelsdorp, associate professor at the University of Maryland (UMD) in Entomology named for the fifth year in a row for his work in honey bee and pollinator health, Yiping Qi, ...

Advances in gene-editing technology enable efficient, targeted ex vivo engineering of different cell types, which offer a potential therapeutic platform for most challenging disease areas. CRISPR ...

The CRISPR toolbox is continuously evolving, notably in the expansion of Cas enzymes available for gene editing. Both the discovery of new Cas enzymes and the enhancement of previously known Cas ...

Scientists have created a newly engineered variant of the famed gene editing tool CRISPR-Cas9. SpRY removes the barriers of what can and can't be targeted for gene editing, making it possible for the ...