Obesity associated with hypothalamic dysfunction was initially described in patients with craniopharyngioma. Hypothalamic obesity may also result from brain radiation, infection (eg, tuberculosis), ...

Picking the Right Patient for Human Epidermal Growth Factor Receptor 3–Targeted Therapy in Platinum-Resistant Ovarian Cancer The Oncology Grand Rounds series is designed to place original reports ...

Obesity is associated with mitochondrial dysfunction in the hypothalamus resulting from decreased levels of the mitochondrial chaperone Hsp60, a new study by Kleinridders et al. reports. The ...

Hypothalamic obesity is a complex condition that doesn’t always respond to traditional weight loss methods. Medications, hormonal therapy, and surgery may be necessary to see results. Hypothalamic ...

This is due to epigenetic components: microRNA, histone and DNA methylation, gene mutations that alter the expression and production of the neurotrophic factor BDNF, which interacts with the receptors ...

A number of studies have reported an increased incidence of hypothalamic–pituitary dysfunction following traumatic brain injury or subarachnoid hemorrhage, and infections of the central nervous system ...

Please discuss the cause of ovulatory dysfunction in relation to subfertility. With anovulation, central defects (hypothalamic or pituitary) and ovarian failure have to be considered. Measurement of ...

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population. This syndrome encompasses a range of conditions, including obesity, type 2 diabetes ...

Please provide your email address to receive an email when new articles are posted on . Signs of functional hypothalamic amenorrhea include early estrogen loss and anovulation. The condition is often ...