Fluorescent probing of mitochondrial membrane potential (ΔΨm) has emerged as an indispensable tool for interrogating mitochondrial function and tracking the early stages of apoptosis. Lipophilic ...

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the ...

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. But it is just as important to resolve that inflammation and return ...

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the metabolism of the cell, they also play a key role in the integration of signals ...

A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David ...

(1) Mitochondrial failure, where aging reduces compensatory mtDNA replication, leads to ROS accumulation, respiratory chain damage (NADH/CoQ deficiency), and membrane potential collapse. These defects ...

A newly identified identified cellular mechanism allows mitochondria to recycle localized damage and maintain healthy function. Mitochondria, the so-called "powerhouse of the cell," depend on a newly ...

Copper is essential for life. Our cells need the metal to make energy and stay healthy, but if it is in the wrong place or ...

A new study offers a fresh perspective on the role of sodium in mitochondrial physiology and points the way to future research into the relationship between complex I disorders and a host of neuronal ...

Jesús Vázquez Cobos, Iván López-Montero, Enrique Calvo Alcocer, Pablo Hernansanz Agustín, Carmen Morales Vidal, José Antonio Enríquez, Rebeca Acín Pérez, Sara Jaroszewicz and José Luis Cabrera Alarcón ...