Findings show that impaired autophagy leads to muscle degeneration, inflammation, and mitochondrial defects, while ...

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

Researchers at the Wellcome Sanger Institute and at Sun Yat-sen University have generated what they claim is the first comprehensive atlas of aging muscles in humans. The team applied single-cell ...

An international research team with the participation of researchers from the University Medical Center Göttingen (UMG), ...

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically ...

DECEMBER 3, 2025—(BRONX, NY)—Two related studies published today in Nature Metabolism show that a specialized intracellular recycling mechanism—chaperone-mediated autophagy (CMA)—is essential for ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers at the University Hospital Bonn have identified a breakdown in autophagy, the cell’s recycling system, as the primary cause of myofibrillar myopathy type 6 (MFM6). Using a humanized mouse ...

A research team has found that specific immune cells can connect with muscle fibers in a lightning-fast, neuron-like way to promote healing. These cells deliver quick pulses of calcium, triggering ...

PICALM, a protein boosted by exercise and fasting, plays a critical role in muscle cell development. It controls cellular transport, and structure, with implications for preventing age-related muscle ...