Astrocyte NF-κB activation triggers harmful inflammation and poorer recovery after traumatic brain injury, finds study

A fall on the head, a blow to the skull, or a road traffic accident—the causes of traumatic brain injury are diverse, but the ...
BioWorld

New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect

The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
Medical Xpress

Amino Acids, Peptides, and Proteins: News and Research on NF-kappa B

A new paper by Dana-Farber Cancer Institute scientists lays the foundation for targeted therapies to inhibit the activation of nuclear factor kappa B (NF-κB), a transcription factor that plays a role ...
ascopubs.org

Effect of dopamine receptor D2 on NF-κB signal pathway abrogation in non-small cell lung cancer cells.

Functional annotation of cancer driver genes in breast cancer patient-derived xenografts to identify a novel target for PARP inhibitors.
BioWorld

PILA identified as lncRNA that enhances NF-kappaB signaling and osteoarthritis

New research points a finger at a previously unknown long noncoding RNA (lncRNA) as playing a critical role in activating nuclear factor kappa B (NF-kappaB) inflammatory responses and driving the ...
EurekAlert!

Regulation of the Canonical and Non-Canonical NF-κB Pathways (IMAGE)

The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...