Sites of action of opioids for pain relief include the brain (cortex, thalamus, hypothalamus, locus coeruleus, amygdala, and periaqueductal gray matter), spinal cord, and peripheral-nerve membrane.

Cardiac surgery With the increasing number of patients presenting to surgery with opioid tolerance, clinicians should be familiar with their specific analgesic needs. Due to the increased use and ...

Targets to eliminate pain after surgery are a major cause of the opioid crisis in several countries, according to a new report co-authored by Professor Lesley Colvin of the University of Dundee.

Opioids are powerful painkillers but their use is hindered because patients become tolerant to them, requiring higher and higher doses, and overdoses can cause respiratory depression and death. A ...

UF Scripps Biomedical Research scientists have a discovered a key gene that is shedding light on how people develop tolerance to pain-relievers over time, a problem that raises risk of addiction and ...

The opioid epidemic in the United States has exacted an incalculable toll on individuals and communities, creating an urgent need for alternative painkillers. The search for non-opioid treatments is ...