Colorectal cancer is the third most common cancer in the United States. Although screening has led to a decrease in incidence over the past 20 years, early-onset colorectal cancer has been rising.

Researchers uncover how manual acupuncture targets spinal inflammation to relieve rheumatoid arthritis pain. Read more!

Effect of 2G8, a TGF-beta-R2 inhibitor, on TGF-beta signaling and migration in an immunocompetent pancreatic cancer model. Background: Chemokine receptors have been shown to regulate the progression ...

Investor attention is turning to Tvardi Therapeutics as the biopharmaceutical company approaches several significant clinical data readouts in the first half of ...

“Our study emphasizes the importance of distinguishing between STAT3α and STAT3β proteins and their active forms when discussing STAT3-related cancer diagnosis and therapy.” Signal transducer and ...

Induced protein degradation can potentially be used to therapeutically modulate previously ‘undruggable’ targets, such as transcription factors. In Cancer Cell, Bai and colleagues now report a ...

VVD-130850 is an investigational oral small molecule inhibitor of STAT3 transcription factor developed for treatment of advanced solid and hematologic tumors as a single agent and in combination with ...

Figure 1: (A) Canonical STAT3 activation pathway. (B) WP1066 and TTI-101, examples of small molecule STAT3 inhibitors that are cell penetrant. Pediatric H3K27M-mutant diffuse midline gliomas (DMGs), ...

Recludix Pharma Inc. has divulged signal transducer and activator of transcription 3 (STAT3) and 6 (STAT6) inhibitors reported to be useful for the treatment of cancer and inflammation.

New research reveals how a cancer-associated protein enables tumor cells to evade the immune system by both suppressing anti-tumor influences and promoting tumor-enhancing conditions, in essence ...