Toll-like receptors (TLRs) are type I transmembrane proteins that are involved in innate and adaptive immune responses to pathogens and are found on the surface of cells and in endosomal compartments.

SRp38 is an atypical SR protein that functions as a general splicing repressor when dephosphorylated. We now show that phosphorylated SRp38 functions as a sequence-specific splicing activator. Unlike ...