(See K.R. Koehler et al., “Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells,” Nature Biotechnology, doi:10.1038/nbt.3840, 2017.) ...

Forming sensory organs requires complicated interactions between numerous cell types. Building these tissues in a dish from human stem cells helps researchers understand how they develop over time and ...

Nuclei (cyan/teal) surround luminal cavities (black), with epithelial boundaries and apical surfaces, with stereocilia, highlighted (green), and enriched sensory hair cell domains visible in magenta.

Acquisition of desirable organoid cultures depends on the introduction of a variety of cytokine combinations into an organoid media. Based on the cell source and the final differentiation type, these ...