Extrachromosomal DNA (abbreviated ecDNA) is any DNA that is found off the chromosomes, either inside or outside the nucleus of a cell. Most DNA in an individual genome is found in …

Jan 3, 2025 · A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) — acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, …

Sep 1, 2025 · This review discusses open questions on the evolutionary role of extrachromosomal DNA (ecDNA) in tumor development, including tumorigenesis and metastatic seeding.

May 25, 2023 · Extrachromosomal DNA (ecDNA) is a special class of circular DNA in eukaryotes, which is independent of conventional chromosomes. These circular molecules play important …

Jun 3, 2025 · Focal amplifications on ecDNAs are commonly found in cancer and are associated with poor patient outcomes and distinct biology. In this review, we provide a guide to ecDNA …

Sep 15, 2025 · In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. …

A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) — acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, distinct from …

Unlike traditional Mendelian inheritance, which involves equal contributions from both parents through nuclear DNA, extrachromosomal inheritance typically involves traits inherited from the …

The meaning of EXTRACHROMOSOMAL is situated or controlled by factors outside the chromosome. How to use extrachromosomal in a sentence.

Feb 26, 2024 · Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to cancer pathogenesis that is identified in most cancer types and is associated …