A major immunotherapeutic modality is immune checkpoint blockades (ICBs), which rely on antibodies to prevent cancer cells from activating checkpoint mechanisms in T cells and other …

4 days ago · The immune system performs immunosurveillance to detect and eliminate abnormal cells within the body. This protective mechanism is highly effective at destroying nascent …

5 days ago · Immunology December 15, 2025 Stanford Medicine study identifies immune switch critical to autoimmunity, cancer By Krista Conger A molecule involved in red blood cell …

May 10, 2024 · Authors note that tumors likely employ a variety of strategies to evade immune detection. But the discovery could lead to a new approach for targeted cancer therapies.

10 hours ago · Researchers demonstrated that newly developed molecules designed to block an immune checkpoint can trigger a powerful immune response against tumors. Scientists at MIT …

Nov 3, 2025 · By activating an immune signaling pathway inside cancer cells, MIT researchers found a way to force tumors to produce a molecule that leads to their own destruction.

Nov 27, 2025 · Recent studies suggest that tumor cells may hijack CD300a-associated pathways to establish an immunosuppressive microenvironment that facilitates immune evasion, tumor …

Dec 11, 2025 · What is already known on this topic Macrophage “don’t-eat-me” checkpoints, such as CD47 and CD24, enable tumors to evade innate immune clearance. Although anti-CD47 …

Nov 4, 2025 · By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT researchers have found a way to force tumors to trigger their own …

Jan 4, 2024 · We investigate the rationale for concurrently targeting numerous checkpoints in order to restore and strengthen anticancer immunity.